As much as fourteen hundred years ago, during China's Eastern Han Dynasty, a sea route, although not part of the formal Silk Route, led from the mouth of the Red River near modern Hanoi, through the Malacca Straits to Southeast Asia, Sri Lanka and India, and then on to the Persian Gulf and the Red Sea kingdom of Axum and eventual Roman ports. From ports on the Red Sea goods, including silks, were transported overland to the Nile and then to Alexandria from where they were shipped to Rome, Constantinople and other Mediterranean ports.

The Maritime Silk Road extends from Guangzhou, located in southern China, to present day Brunei, Myanmar (Burma) Thailand, Malacca, Ceylon, India, Pakistan, the Philippines, Iran and Iraq. In Europe it extends from Israel, Lebanon (Collectively, the Levant), Egypt, and Italy (Historically Venice) in the Mediterranean Sea to other European ports or caravan routes such as the great Hanseatic League fairs via the Spanish road and other Alpine routes.